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0 0.5 1 1.5 2+ Case 5% Improvement Relative Risk c19hcq.com Abella et al. HCQ for COVID-19 RCT PrEP Favors HCQ Favors control
Abella, 125 patient HCQ prophylaxis RCT: 5% fewer cases [p=1] https://c19p.org/abella
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Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers
Abella et al., JAMA Internal Medicine, doi:doi:10.1001/jamainternmed.2020.6319
30 Sep 2020    Source   PDF   Share   Tweet
Very small early-terminated underpowered PrEP RCT with 64/61 HCQ/control patients and only 8 infections, HCQ infection rate 6.3% versus control 6.6%, RR 0.95 [0.25 - 3.64].
There was no hospitalization or death, no significant difference in QTc, no severe adverse events, no cardiac events (e.g., syncope and arrhythmias) observed. Medication adherence was 81%. Therapeutic levels of HCQ may not have been reached by the time of the infection in the first week.
2 infections were reported to be after discontinuation of the medication, but the authors do not specify which arm these were in. Hypothetically, if these were both in the HCQ arm, the resulting RR for treatment would be much lower.
risk of case, 5.0% lower, RR 0.95, p = 1.00, treatment 4 of 64 (6.2%), control 4 of 61 (6.6%), NNT 325.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abella et al., 9/30/2020, Randomized Controlled Trial, USA, North America, peer-reviewed, 18 authors.
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