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0 0.5 1 1.5 2+ Hospitalization 95% Improvement Relative Risk Severity 27% Case -5% c19hcq.com Agarwal et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Agarwal, 484 patient HCQ prophylaxis study: 27% lower progression [p=0.21] and 5% more cases [p=0.81] https://c19p.org/agarwal2
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Low dose hydroxychloroquine prophylaxis for COVID-19 - a prospective study
Agarwal et al., medRxiv, doi:10.1101/2021.09.13.21262971 (Preprint)
14 Sep 2021    Source   PDF   Share   Tweet
Small prophylaxis trial with 29 low dose HCQ and 455 control healthcare workers in India, showing no statistically significant differences.
risk of hospitalization, 94.8% lower, RR 0.05, p = 0.61, treatment 0 of 29 (0.0%), control 17 of 455 (3.7%), NNT 27, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
relative severity, 26.9% better, RR 0.73, p = 0.21, treatment 29, control 455.
risk of case, 4.6% higher, RR 1.05, p = 0.81, treatment 6 of 29 (20.7%), control 90 of 455 (19.8%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Agarwal et al., 9/14/2021, prospective, India, South Asia, preprint, 1 author.
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