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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Progression 68% Improvement Relative Risk Time to viral- 32% no CI c19hcq.com/agusti.html Favors HCQ Favors control
9 December 2020 - Early treatment study
Efficacy and safety of hydroxychloroquine in healthcare professionals with mild SARS-CoV-2 infection: prospective, non-randomized trial
Agusti et al., Enfermedades Infecciosas y MicrobiologĂ­a ClĂ­nica, doi:10.1016/j.eimc.2020.10.023 (Peer Reviewed)
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Small trial of low dose HCQ for healthcare workers with mild SARS-CoV-2 showing 68% lower progression to pneumonia, p = 0.21, and faster, but not statistically significant viral clearance. There were no ICU admissions or deaths. Prospective non-randomized study. The figures and supplementary data are not currently available in the pre-proof edition.
risk of progression, 68.4% lower, RR 0.32, p = 0.21, treatment 2 of 87 (2.3%), control 4 of 55 (7.3%), NNT 20, pneumonia.
time to viral-, 31.8% lower, relative time 0.68, treatment 87, control 55.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Agusti et al., 12/9/2020, prospective, Spain, Europe, peer-reviewed, median age 37.0, 13 authors, average treatment delay 5.0 days, dosage 400mg bid day 1, 200mg bid days 2-5.
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