et al., Tohoku J. Exp. Med., 2020, 252, 73-84, doi:10.1620/tjem.252.73 (Peer Reviewed)
Retrospective 459 patients in Iran 93% using HCQ, showing HCQ mortality RR 0.45, p
= 0.028. HCQ was the only antiviral that showed a significant difference. Small number of control patients and subject to confounding by indication. Average admission delay 5.72 days.
Alamdari et al., 9/9/2020, retrospective, Iran, West Asia, peer-reviewed, 14 authors.
risk of death, 55.0% lower, RR 0.45, p = 0.03, treatment 427, control 32.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.