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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 81% Improvement Relative Risk c19vitamind.com/alcaladiaz.html Favors vitamin D Favors control
21 May 2021 - Late treatment study
Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study
Alcala-Diaz et al., Nutrients, doi:10.3390/nu13061760 (Peer Reviewed)
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Retrospective 537 patients in Spain, 79 treated with calcifediol, showing significantly lower mortality with treatment. The treated group had a higher risk of comorbidity, whereas the control group had lower O2 saturation, higher CURB‐65, and higher ARDS (serverity measures were included in the multivariate analysis).
risk of death, 80.8% lower, RR 0.19, p = 0.04, treatment 4 of 79 (5.1%), control 90 of 458 (19.7%), NNT 6.9, adjusted per study, odds ratio converted to relative risk, day 30, multivariate logistic regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Alcala-Diaz et al., 5/21/2021, retrospective, Spain, Europe, peer-reviewed, 17 authors, dosage calcifediol 0.5mg day 1, 0.27mg day 3, 0.27mg day 7, 0.27mg day 14, 0.27mg day 21, 0.27mg day 28.
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