Finding the Dose for Hydroxychloroquine Prophylaxis for COVID‐19: The Desperate Search for Effectiveness

6/1 N/A

Al-Kofahi et al., Clin. Pharmacol. Ther., Jun 1, 2020, doi:10.1002/cpt.1874 (Peer Reviewed)
Finding the Dose for Hydroxychloroquine Prophylaxis for COVID‐19: The Desperate Search for Effectiveness

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Analysis of HCQ dosing regimens, recommending:

PrEP: 800mg loading dose followed by 400mg 2 or 3 times weekly to maintain weekly troughs above EC₅₀ in >50% of patients at steady-state.

PEP: 800mg loading dose followed in 6 hours by 600mg, then 600mg daily for 4 more days to achieve daily troughs above EC₅₀ in >50% subjects.

Al-Kofahi et al., 6/1/2020, peer-reviewed, 9 authors.

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