Clinical characteristics and predictors of the duration of hospital stay in COVID-19 patients in Jordan
Rami S Alqassieh, Isam K Bsisu, Mohammed Qussay Al-Sabbagh, Naser M El-Hammuri, Moh’d A Yousef, Mohammad A El Jarbeh, Ahmed A Sharqawi, Heba Z Smadi, Sami A Abu-Halaweh, Mohammad M Abufaraj
F1000Research, doi:10.12688/f1000research.27419.1
Background: On March 11th, 2020, the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a global pandemic. Healthcare systems in low-and middle-income countries may face serious limitations during a pandemic, for which understanding the predictors of prolonged hospital stay are crucial in decreasing the mortality rate. The aim of this study was to investigate the predictors of increased length of hospitalization among COVID-19 patients. Methods: In this prospective study, we investigated the effect of presenting symptoms and laboratory investigations on the duration of hospitalization of 131 COVID-19 patients at a tertiary hospital in Jordan from March 17th to April 9th, 2020. Results: Patients median age was 24 years [interquartile range (IQR): 8-39], of which 67 (51.15%) were males and 64 (48.85%) were females. Smokers had shorter in-hospital stay (OR: -3.52; 95% CI: -6.73 to -0.32; P=0.03). Taste loss (OR: 5.1; 95% CI: 1.95 to 8.25; P<0.01) and chills or rigors (OR: 4.08; 95% CI: 0.73 to 7.43; P=0.02) were the symptoms significantly associated with increased in-hospital stay, while those who had malaise (OR: -4.98; 95% CI: -8.42 to -1.59; P<0.01) and high white blood cell (WBC) count (OR: -0.74; 95% CI: -1.31 to -0.17; P=0.01) had faster recovery. Conclusions: Our study found that the most common presenting Open Peer Review Reviewer Status
References
Bsisu, Alqassieh, Abu-Halaweh, Clinical characteristics and predictors of the duration of hospital stay in COVID-19 patients in Jordan,
doi:10.7910/DVN/SBV1K6
Chen, Wu, Guo, Clinical and immunological features of severe and moderate coronavirus disease 2019, J Clin Invest,
doi:10.1172/JCI137244
Chen, Zhou, Dong, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet,
doi:10.1016/S0140-6736(20)30211-7
Dreher, Kersten, Bickenbach, The Characteristics of 50 Hospitalized COVID-19 Patients With and Without ARDS, Dtsch Arztebl Int,
doi:10.3238/arztebl.2020.0271
El-Aziz, Stockand, Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) -an update on the status, Infect Genet Evol,
doi:10.1016/j.meegid.2020.104327
Farsalinos, Niaura, Houezec, Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system, Toxicol Rep,
doi:10.1016/j.toxrep.2020.04.012
Fatima, Asif, Khan, Comparison of efficacy of dexamethasone and methylprednisolone in moderate to severe covid 19 disease, Ann Med Surg (Lond),
doi:10.1016/j.amsu.2020.11.027
Horby, Lim, Dexamethasone in Hospitalized Patients with Covid-19 -Preliminary Report, N Engl J Med,
doi:10.1056/NEJMoa2021436
Lai, Shih, Ko, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges, Int J Antimicrob Agents,
doi:10.1016/j.ijantimicag.2020.105924
Li, Guan, Wu, Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia, N Engl J Med,
doi:10.1056/NEJMoa2001316
Mcmichael, Currie, Clark, Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington, N Engl J Med,
doi:10.1056/NEJMoa2005412
Mehra, Desai, Ruschitzka, RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, The Lancet,
doi:10.1016/S0140-6736(20)31180-6
Munster, Koopmans, Van Doremalen, A Novel Coronavirus Emerging in China -Key Questions for Impact Assessment, N Engl J Med,
doi:10.1056/NEJMp2000929
Peeri, Shrestha, Rahman, The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned?, Int J Epidemiol,
doi:10.1093/ije/dyaa033
Rio, Malani, Translating Science on COVID-19 to Improve Clinical Care and Support the Public Health Response, JAMA,
doi:10.1001/jama.2020.9252
Spinato, Fabbris, Polesel, Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection, JAMA,
doi:10.1001/jama.2020.6771
Suleiman, Bsisu, Guzu, Preparedness of Frontline Doctors in Jordan Healthcare Facilities to COVID-19 Outbreak, Int J Environ Res Public Health,
doi:10.3390/ijerph17093181
Vaira, Salzano, Deiana, Anosmia and Ageusia: Common Findings in COVID-19 Patients, Laryngoscope,
doi:10.1002/lary.28692
Weiss, Navas-Martin, Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus, Microbiol Mol Biol Rev
Yusef, Hayajneh, Awad, Large Outbreak of Coronavirus Disease among Wedding Attendees, Jordan, Emerg Infect Dis,
doi:10.3201/eid2609.201469
Zhang, Yan, Fan, D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19, J Thromb Haemost
Zhou, Yu, Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet,
doi:10.1016/S0140-6736(20)30566-3