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0 0.5 1 1.5 2+ Viral clearance, day 5 15% primary Improvement Relative Risk Viral clearance, day 12 25% c19hcq.com Alwafi et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Alwafi, 93 patient HCQ late treatment study: 15% improved viral clearance [p=0.65] https://c19p.org/alwafi
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Negative Nasopharyngeal SARS-CoV-2 PCR Conversion in Response to Different Therapeutic Interventions
Alwafi et al., Cureus, doi:10.7759/cureus.21442
20 Jan 2022    Source   PDF   Share   Tweet
Retrospective 93 hospitalized patients in Saudi Arabia, 45 treated with CQ/HCQ, showing no significant difference in viral clearance. More patients treated with CQ/HCQ had severe cases at baseline (20% vs. 2%).
risk of no viral clearance, 14.7% lower, RR 0.85, p = 0.65, treatment 12 of 45 (26.7%), control 15 of 48 (31.2%), NNT 22, day 5, primary outcome.
risk of no viral clearance, 25.3% lower, RR 0.75, p = 0.60, treatment 7 of 45 (15.6%), control 10 of 48 (20.8%), NNT 19, day 12.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups.
Alwafi et al., 20 Jan 2022, retrospective, Saudi Arabia, peer-reviewed, 6 authors, study period 7 March, 2020 - 15 April, 2020.
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