Clinical characteristics and outcome of COVID-19 in patients with rheumatic diseases

4/15 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Alzahrani et al., Rheumatology International , doi:10.1007/s00296-021-04857-9 (Peer Reviewed)
Clinical characteristics and outcome of COVID-19 in patients with rheumatic diseases

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Retrospective 47 rheumatic disease patients not finding significant differences with HCQ.

Alzahrani et al., 4/15/2021, retrospective, Saudi Arabia, Middle East, peer-reviewed, 3 authors.

risk of death, 58.8% lower, RR 0.41, p = 1.00, treatment 0 of 14 (0.0%), control 1 of 33 (3.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).

risk of mechanical ventilation, 81.0% lower, RR 0.19, p = 0.54, treatment 0 of 14 (0.0%), control 3 of 33 (9.1%), continuity correction due to zero event (with reciprocal of the contrasting arm).

risk of COVID-19 severe case, 32.7% lower, RR 0.67, p = 0.70, treatment 2 of 14 (14.3%), control 7 of 33 (21.2%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 344 studies Meta Analysis

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