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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 59% Improvement Relative Risk Mechanical ventilation 81% Severe case 33% c19hcq.com/alzahrani.html Favors HCQ Favors control
15 April 2021 - Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Clinical characteristics and outcome of COVID-19 in patients with rheumatic diseases
Alzahrani et al., Rheumatology International , doi:10.1007/s00296-021-04857-9 (Peer Reviewed)
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Retrospective 47 rheumatic disease patients not finding significant differences with HCQ.
risk of death, 58.7% lower, RR 0.41, p = 1.00, treatment 0 of 14 (0.0%), control 1 of 33 (3.0%), NNT 33, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of mechanical ventilation, 81.0% lower, RR 0.19, p = 0.54, treatment 0 of 14 (0.0%), control 3 of 33 (9.1%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of severe case, 32.7% lower, RR 0.67, p = 0.70, treatment 2 of 14 (14.3%), control 7 of 33 (21.2%), NNT 14.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Alzahrani et al., 4/15/2021, retrospective, Saudi Arabia, Middle East, peer-reviewed, 3 authors.
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