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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Not reaching lowest sy.. 60% Improvement Relative Risk Time to first occurren.. 43% Time to release from q.. 27% c19hcq.com/amaravadi.html Favors HCQ Favors control
26 February 2021 - Early treatment study
Hydroxychloroquine for SARS-CoV-2 positive patients quarantined at home: The first interim analysis of a remotely conducted randomized clinical trial
Amaravadi et al., medRxiv, doi:10.1101/2021.02.22.21252228 (Preprint)
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Tiny early-terminated 34 patient RCT for outpatient treatment showing faster recovery with treatment (not statistically significant). All patients recovered (3 control patients recovered after crossover to the treatment arm). There was no mortality and only one hospitalization on day 0 before treatment. There were no severe adverse events.
risk of not reaching lowest symptom score at day 7 mid-recovery, 60.0% lower, RR 0.40, p = 0.13, treatment 3 of 15 (20.0%), control 6 of 12 (50.0%), NNT 3.3.
relative time to first occurrence of lowest symptom score, 42.9% lower, relative time 0.57, p = 0.21, treatment 15, control 12.
relative time to release from quarantine, 27.3% lower, relative time 0.73, p = 0.28, treatment 16, control 13.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Amaravadi et al., 2/26/2021, Double Blind Randomized Controlled Trial, USA, North America, preprint, 20 authors, dosage 400mg bid days 1-14.
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