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0 0.5 1 1.5 2+ Mortality 4% Improvement Relative Risk Mortality (b) -21% c19hcq.com Annie et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Annie, 734 patient HCQ late treatment study: 4% lower mortality [p=0.83] https://c19p.org/annie
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Hydroxychloroquine in hospitalized COVID‐19 patients: Real world experience assessing mortality
Annie et al., Pharmacotherapy, doi:10.1002/phar.2467
12 Oct 2020    Source   PDF   Share   Tweet
Retrospective database analysis with PSM not including COVID-19 severity, finding mortality OR 0.95 [0.62-1.46] for HCQ, and 1.24 [0.70-2.22] for HCQ+AZ. Confounding by indication likely.
risk of death, 4.3% lower, RR 0.96, p = 0.83, treatment 48 of 367 (13.1%), control 50 of 367 (13.6%), NNT 183, odds ratio converted to relative risk.
risk of death, 20.5% higher, RR 1.21, p = 0.46, treatment 29 of 199 (14.6%), control 24 of 199 (12.1%), odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: confounding by indication is likely and adjustments do not consider COVID-19 severity at baseline.
Annie et al., 10/12/2020, retrospective, database analysis, USA, North America, peer-reviewed, 5 authors.
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