Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19

10/8 Late treatment study

Aparisi et al., medRxiv, doi:10.1101/2020.10.06.20207092 (Preprint)
Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19

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Retrospective 654 hospitalized patients focused on low-density lipoprotein cholesterol levels, also showing results for HCQ with 605 HCQ patients, unadjusted 30 day mortality relative risk RR 0.37, p = 0.008.

Aparisi et al., 10/8/2020, prospective, Spain, Europe, preprint, 18 authors.

risk of death, 63.0% lower, RR 0.37, p = 0.008, treatment 122 of 605 (20.2%), control 27 of 49 (55.1%).

This study is excluded in meta analysis: unadjusted results with no group details.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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