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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 50% Improvement Relative Risk Mortality (b) 52% c19hcq.com/arleo.html Favors HCQ Favors control
27 October 2020 - Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Clinical Course and Outcomes of coronavirus disease 2019 (COVID-19) in Rheumatic Disease Patients on Immunosuppression: A case Cohort Study at a Single Center with a Significantly Diverse Population
Arleo et al., medRxiv, doi:10.1101/2020.10.26.20219154 (Preprint)
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Retrospective hospitalized rheumatic disease patients showing 50% lower mortality for patients on HCQ.
risk of death, 50.0% lower, RR 0.50, p = 0.67, treatment 1 of 20 (5.0%), control 5 of 50 (10.0%), NNT 20, all patients.
risk of death, 52.0% lower, RR 0.48, p = 0.64, treatment 1 of 10 (10.0%), control 5 of 24 (20.8%), NNT 9.2, inpatients.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Arleo et al., 10/27/2020, retrospective, USA, North America, preprint, 5 authors.
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