COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes

4/24 Early treatment study

Ashraf et al., medRxiv doi:10.1101/2020.04.20.20072421.t (Preprint)
COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes

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Small limited trial with 100 patients concluding that HCQ improved clinical outcome, OR 0.016 [0.002-0.11] in regression analysis.

Ashraf et al., 4/24/2020, retrospective, database analysis, Iran, Middle East, preprint, median age 58.0, 16 authors, dosage 200mg bid daily, 400mg qd was used when combined with Lopinavir-Ritonavir.

risk of death, 67.5% lower, RR 0.32, p = 0.15, treatment 10 of 77 (13.0%), control 2 of 5 (40.0%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 344 studies Meta Analysis

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