Hydroxychloroquine for SARS CoV2 Prophylaxis in Healthcare Workers – A Multicentric Cohort Study Assessing Effectiveness and Safety

6/7 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Badyal et al., Journal of the Association of Physicians of India, Volume 69, June 2021 (Peer Reviewed)
Hydroxychloroquine for SARS CoV2 Prophylaxis in Healthcare Workers – A Multicentric Cohort Study Assessing Effectiveness and Safety

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Prophylaxis study with 12,089 Indian healthcare workers, showing lower risk of COVID-19 cases with treatment, and increasingly lower risk for longer durations of HCQ prophylaxis. The appendices are not currently available.

Badyal et al., 6/7/2021, prospective, India, South Asia, peer-reviewed, 18 authors.

risk of COVID-19 case, 60.1% lower, RR 0.40, p < 0.001, treatment 247 of 617 (40.0%), control 611 of 1473 (41.5%), adjusted per study, odds ratio converted to relative risk, >=6 weeks, logistic regression.

risk of COVID-19 case, 35.1% lower, RR 0.65, p < 0.001, treatment 88 of 185 (47.6%), control 611 of 1473 (41.5%), adjusted per study, odds ratio converted to relative risk, 4-5 weeks, logistic regression.

risk of COVID-19 case, 23.2% lower, RR 0.77, p = 0.002, treatment 80 of 181 (44.2%), control 611 of 1473 (41.5%), adjusted per study, odds ratio converted to relative risk, 2-3 weeks, logistic regression.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 344 studies Meta Analysis

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