Recent Hydroxychloroquine Use Is Not Significantly Associated with Positive PCR Results for SARS-CoV-2: A Nationwide Observational Study in South Korea

2/20 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Bae et al., Viruses 2021, doi:10.3390/v13020329 (Peer Reviewed)
Recent Hydroxychloroquine Use Is Not Significantly Associated with Positive PCR Results for SARS-CoV-2: A Nationwide Observational Study in South Korea

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Retrospective database analysis of prior HCQ usage in South Korea, showing non-statistically significantly lower mortality and cases with treatment.

Bae et al., 2/20/2021, retrospective, South Korea, Asia, peer-reviewed, 8 authors.

risk of COVID-19 case, 30.3% lower, RR 0.70, p = 0.17, treatment 16 of 743 (2.2%), control 91 of 2698 (3.4%), odds ratio converted to relative risk, PSM.

risk of COVID-19 case, 19.5% lower, RR 0.81, p = 0.49, treatment 16 of 743 (2.2%), control 91 of 2698 (3.4%), odds ratio converted to relative risk, PSM, adjusted for region.

risk of COVID-19 case, 30.3% lower, RR 0.70, p = 0.29, treatment 16 of 743 (2.2%), control 91 of 2698 (3.4%), odds ratio converted to relative risk, PSM, adjusted for immunosuppresant use.

risk of COVID-19 case, 40.2% lower, RR 0.60, p = 0.08, odds ratio converted to relative risk, PSM, HCQ >= 6 months.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 320 studies Meta Analysis

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