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0 0.5 1 1.5 2+ Mortality 63% Improvement Relative Risk Respiratory deterioration.. 25% Discharge -12% c19hcq.com Beltran Gonzalez et al. NCT04391127 HCQ RCT LATE Favors HCQ Favors control
Beltran Gonzalez, 70 patient HCQ late treatment RCT: 63% lower mortality [p=0.27] and 25% lower progression [p=0.57] https://c19p.org/beltrangonzalezh
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Efficacy and Safety of Ivermectin and Hydroxychloroquine in Patients with Severe COVID-19: A Randomized Controlled Trial
Beltran Gonzalez et al., Infectious Disease Reports, doi:10.3390/idr14020020 (preprint 2/23/2021)
23 Feb 2021    Source   PDF   Share   Tweet
RCT late stage severe condition (93% SOFA ≥ 2, 96% APACHE ≥ 8) high comorbidity hospitalized patients in Mexico with 33 HCQ and 37 control patients not finding significant differences. NCT04391127.
risk of death, 62.6% lower, RR 0.37, p = 0.27, treatment 2 of 33 (6.1%), control 6 of 37 (16.2%), NNT 9.8.
risk of respiratory deterioration or death, 25.3% lower, RR 0.75, p = 0.57, treatment 6 of 33 (18.2%), control 9 of 37 (24.3%), NNT 16.
risk of no hospital discharge, 12.1% higher, RR 1.12, p = 1.00, treatment 3 of 33 (9.1%), control 3 of 37 (8.1%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Beltran Gonzalez et al., 2/23/2021, Double Blind Randomized Controlled Trial, Mexico, North America, peer-reviewed, mean age 53.8, 13 authors, average treatment delay 7.0 days, trial NCT04391127.
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