et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2020.07.024 (Peer Reviewed)
Retrospective 4035 hospitalized patients in Spain showing reduced mortality with HCQ (data is in the supplementary appendix).
Berenguer et al., 8/3/2020, retrospective, Spain, Europe, peer-reviewed, 8 authors.
risk of death, 61.9% lower, RR 0.38, p < 0.001, treatment 681 of 2618 (26.0%), control 939 of 1377 (68.2%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.