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0 0.5 1 1.5 2+ Mortality 59% Improvement Relative Risk c19hcq.com Bernabeu-Wittel et al. HCQ for COVID-19 EARLY Favors HCQ Favors control
Bernabeu-Wittel, 272 patient HCQ early treatment study: 59% lower mortality [p=0.03] https://c19p.org/bernabeuwittel
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Effectiveness of a On-Site Medicalization Program for Nursing Homes with COVID-19 Outbreaks
Bernabeu-Wittel et al., J. Gerontol. A Biol. Sci. Med. Sci., doi:10.1093/gerona/glaa192
1 Aug 2020    Source   PDF   Share   Tweet
Retrospective 272 nursing home residents showing significantly improved survival after establishing a treatment program including HCQ with or without lopinavir/ritonavir and with the addition of adjuvant and antimicrobial treatments depending on circumstances. Dosage details are in the supplementary appendix. Mortality relative risk is from [Alexander].
risk of death, 59.0% lower, RR 0.41, p = 0.03, treatment 189, control 83.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bernabeu-Wittel et al., 8/1/2020, retrospective, Spain, Europe, peer-reviewed, 13 authors, dosage 400mg bid day 1, 200mg bid days 2-7, this trial uses multiple treatments in the treatment arm (combined with lopinavir/ritonavir and antimicrobial treatments) - results of individual treatments may vary.
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