Observational Study of the Efficiency of Treatments in Patients Hospitalized with Covid-19 in Madrid

Bernaola et al., medRxiv, doi:10.1101/2020.07.17.20155960 (Preprint)
Observational Study of the Efficiency of Treatments in Patients Hospitalized with Covid-19 in Madrid

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HCQ HR 0.83 [0.77-0.89] based on propensity score matched retrospective analysis of 1,645 hospitalized patients. Prednisone HR 0.85 [0.82-0.88], 14 other medications showed either no signicant benefit or a negative effect.

Bernaola et al., 7/21/2020, retrospective, Spain, Europe, preprint, 7 authors.

risk of death, 17.0% lower, RR 0.83, p < 0.001, treatment 236 of 1498 (15.8%), control 28 of 147 (19.0%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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