6/9 Pre-Exposure Prophylaxis study (treated before exposed to the virus)
et al., medRxix, doi:10.1101/2020.06.09.20116806 (Preprint)
Pre exposure Hydroxychloroquine use is associated with reduced COVID19 risk in healthcare workers
Pre exposure Hydroxychloroquine use is associated with reduced COVID19 risk in healthcare workers
HCQ reduced cases from 38% to 7%. 106 people. No serious adverse effects.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Bhattacharya et al., 6/9/2020, retrospective, India, South Asia, preprint, 7 authors.
risk of COVID-19 case, 80.7% lower, RR 0.19, p = 0.001, treatment 4 of 54 (7.4%), control 20 of 52 (38.5%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
