et al, Biosci. Rep., doi:10.1042/BSR20203455 (Peer Reviewed)
Retrospective 258 hospitalized patients in Italy showing lower mortality with HCQ treatment, unadjusted relative risk RR 0.455, p
<0.001. Data is in the supplementary appendix.
Boari et al., 11/17/2020, retrospective, Italy, Europe, peer-reviewed, 20 authors.
risk of death, 54.5% lower, RR 0.45, p < 0.001, treatment 41 of 202 (20.3%), control 25 of 56 (44.6%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.