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All Studies   Meta Analysis   Recent: 
Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety results of a randomized, double-blinded, phase IIb clinical trial (CloroCovid-19 Study)
Borba et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2020.8857
16 Apr 2020    Source   PDF   Share   Tweet
Comparison of typical CQ dosage with high dosage CQ (600mg CQ twice daily for 10 days), showing higher mortality with high dosage, OR 2.8 [0.9 - 8.5] when controlled by age in multivariate analysis.
Increased incidence of prolonged QT and death in high dose treatment arm. Patients >75 only enrolled in high dose arm, age of high dose arm significantly higher than low dose arm (p=0.02). Very sick at baseline, 46% in ICU, 89% on oxygen therapy (this information can be found in the preprint [medrxiv.org]).
Borba et al., 4/16/2020, peer-reviewed, mean age 51.1, 28 authors.
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This PaperHCQAll
Late treatment
is less effective
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