Update: we have not received details for treatment delay. Reportedly, time of dosing was not recorded in these trials: [osf.io]. See [medrxiv.org], and Pullen et al. [ncbi.nlm.nih.gov], which shows shipping delay for these trials of 19 - 68 hours. With enrollment up to 4 days from exposure, this implies delivery 19 - 164 hours after exposure (19 hours would require instantaneous enrollment).COVID-19 cases are reduced by [49%, 29%, 16%] respectively when taken within ~[70, 94, 118] hours of exposure (including shipping delay). The treatment delay-response relationship is significant at p=0.002. PEP delayed treatment RCT.For more detailed analysis, see [c19hcq.com].6 independent analyses of the data in this study confirm efficacy: [arxiv.org, blog.philbirnbaum.com, drive.google.com, longdom.org, medrxiv.org (B), osf.io (B), researchgate.net].Regarding the use of folic acid, see [sciencedirect.com].