Observational prospective 108 hospitalized patients 65 and older, showing HCQ mortality OR 0.49, p
Bousquet et al., 6/23/2020, prospective, France, Europe, peer-reviewed, 10 authors.
risk of death, 42.8% lower, RR 0.57, p = 0.15, treatment 5 of 27 (18.5%), control 23 of 81 (28.4%), adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.