Pharmacology of Chloroquine and Hydroxychloroquine

2014 Animal

Browning, D., Pharmacology of Chloroquine and Hydroxychloroquine, 2014, 35-63, doi:10.1007/978-1-4939-0597-3_2 (Peer Reviewed)
Pharmacology of Chloroquine and Hydroxychloroquine

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Review of the pharmacology of CQ and HCQ. Some notable points:

- HCQ and CQ are equipotent but CQ is more toxic, the therapeutic ratio is higher for HCQ.
- Concentrations in different tissues can vary >10x, in particular the concentration in the lung is much higher in animal experiments.
- Tissue uptake as a function of dosage is nonlinear.

Browning et al., 1/1/2014, peer-reviewed, 1 author.

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