et al., Research Square, doi:10.21203/rs.3.rs-317485/v1 (OSF preprints 3/11) (Preprint)
Systematic review and meta analysis of 21 RCTs finding mortality RR 0.32 [0.14-0.72], and prophylaxis case RR 0.14 [0.09-0.21].
Bryant et al., 3/11/2021, preprint, 7 authors.
risk of death, 68.0% lower, RR 0.32, p = 0.006.
risk of COVID-19 case, 86.0% lower, RR 0.14, p < 0.001.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.