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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 65% Improvement Relative Risk c19hcq.com/budhiraja.html Favors HCQ Favors control
18 November 2020 - Late treatment study
Clinical Profile of First 1000 COVID-19 Cases Admitted at Tertiary Care Hospitals and the Correlates of their Mortality: An Indian Experience
Budhiraja et al., medRxiv, doi:10.1101/2020.11.16.20232223 (Preprint)
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Retrospective 976 hospitalized patients with 834 treated with HCQ+AZ showing HCQ mortality relative risk RR 0.35, p < 0.0001. Note that in this case HCQ was recommended for mild/moderate cases, so more severe cases may not have received HCQ (which may also be why they became severe cases). We note that this is opposite to a common bias in HCQ studies - in many cases HCQ was more likely to be given to more severe cases.
risk of death, 65.4% lower, RR 0.35, p < 0.001, treatment 69 of 834 (8.3%), control 34 of 142 (23.9%), NNT 6.4.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups.
Budhiraja et al., 11/18/2020, retrospective, India, South Asia, preprint, 12 authors.
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