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0 0.5 1 1.5 2+ Recovery time 0% Improvement Relative Risk Improvement in Ct value 29% Viral clearance -3% Viral clearance (b) -7% c19hcq.com Byakika-Kibwika et al. HCQ for COVID-19 RCT LATE Favors HCQ Favors control
Byakika-Kibwika, 105 patient HCQ late treatment RCT: no change in recovery [p=0.91] and 29% improved viral clearance [p=0.47] https://c19p.org/byakikakibwika
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Safety and Efficacy of Hydroxychloroquine for Treatment of Non-Severe COVID-19 in Adults in Uganda: A Randomized Open Label Phase II Clinical Trial
Byakika-Kibwika et al., Research Square, doi:10.21203/rs.3.rs-506195/v1 (Preprint)
4 Jun 2021    Source   PDF   Share   Tweet
Small 105 patient RCT in Uganda showing no significant differences. No mortality was reported. The patients were very young (median age 32), recovering in a median time of 3 days with standard of care, so there is little room for a treatment to make improvements. Time since symptom onset is not specified, but the distribution of symptoms at baseline suggests that the enrollment is relatively late within a cohort of low risk patients.
recovery time, no change, relative time 1.00, p = 0.91, treatment 36, control 29.
relative improvement in Ct value, 29.3% better, RR 0.71, p = 0.47, treatment 15, control 15.
risk of no viral clearance, 2.6% higher, RR 1.03, p = 1.00, treatment 35 of 55 (63.6%), control 31 of 50 (62.0%), day 6.
risk of no viral clearance, 6.7% higher, RR 1.07, p = 0.85, treatment 27 of 55 (49.1%), control 23 of 50 (46.0%), day 10.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Byakika-Kibwika et al., 6/4/2021, Randomized Controlled Trial, Uganda, Africa, preprint, 17 authors.
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Late treatment
is less effective
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