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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -215% Improvement Relative Risk Mechanical ventilation -652% ICU admission -145% Hospitalization time -107% c19hcq.com/calderon2h.html Favors HCQ Favors control
23 November 2021 - Late treatment study
Treatment with hydroxychloroquine vs nitazoxanide in patients with COVID-19: brief report
Calderón et al., PAMJ - Clinical Medicine, doi:10.11604/pamj-cm.2021.7.15.30981 (Peer Reviewed)
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Planned RCT of HCQ vs. HCQ+nitazoxanide which was aborted due to the retracted Surgisphere paper. Authors retrospectively analyze a small set of HCQ vs. nitazoxanide patients (which were protocol deviations in the planned RCT), showing reduced hospitalization time and ICU admission with nitazoxanide.
risk of death, 214.8% higher, RR 3.15, p = 0.38, treatment 5 of 27 (18.5%), control 1 of 17 (5.9%).
risk of mechanical ventilation, 651.9% higher, RR 7.52, p = 0.15, treatment 4 of 27 (14.8%), control 0 of 17 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of ICU admission, 145.5% higher, RR 2.45, p < 0.001, treatment 16 of 27 (59.3%), control 0 of 17 (0.0%), adjusted per study.
hospitalization time, 107.4% higher, relative time 2.07, p = 0.006, treatment 27, control 17.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Calderón et al., 11/23/2021, retrospective, Mexico, North America, peer-reviewed, 7 authors, dosage 200mg bid days 1-7.
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