Small 52 patient retrospective study of patients with acute respiratory failure showing lower rates of intubation with HCQ.
Capsoni et al., 12/1/2020, retrospective, Italy, Europe, preprint, 13 authors.
risk of mechanical ventilation, 40.0% lower, RR 0.60, p = 0.30, treatment 12 of 40 (30.0%), control 6 of 12 (50.0%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.