Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19

5/28 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Chatterjee et al., Indian J. Med. Res., June 20, 2020, doi:10.4103/ijmr.IJMR_2234_20 (Peer Reviewed)
Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19

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4+ doses of HCQ associated with a significant decline in the odds of getting infected, dose-response relationship exists.

Chatterjee et al., 5/28/2020, retrospective, India, South Asia, peer-reviewed, survey, 11 authors.

risk of COVID-19 case, 66.8% lower, RR 0.33, p < 0.001, treatment 12 of 68 (17.6%), control 206 of 387 (53.2%), full course vs. unused.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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