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0 0.5 1 1.5 2+ Radiological progression 29% Improvement Relative Risk Viral+ at day 7 -100% c19hcq.com Chen et al. HCQ for COVID-19 RCT LATE TREATMENT Favors HCQ Favors control
Chen, 30 patient HCQ late treatment RCT: 29% lower progression [p=0.57] and 100% worse viral clearance [p=1] https://c19p.org/chenmedsci
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A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19)
Chen et al., J. Zhejiang University (Med Sci), doi:10.3785/j.issn.1008-9292.2020.03.03
6 Mar 2020    Source   PDF   Share   Tweet
30 moderate hospitalized cases, all recovered. Time to RNA negative comparable. Less frequent radiological progression with HCQ but not statistically significant. One HCQ patient developed to a severe case. Treatment group 4 years older and with higher incidence of hypertension.
risk of radiological progression, 29.0% lower, RR 0.71, p = 0.57, treatment 5 of 15 (33.3%), control 7 of 15 (46.7%), NNT 7.5.
risk of viral+ at day 7, 100% higher, RR 2.00, p = 1.00, treatment 2 of 15 (13.3%), control 1 of 15 (6.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chen et al., 3/6/2020, Randomized Controlled Trial, China, Asia, peer-reviewed, 14 authors.
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Late treatment
is less effective
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