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HCQ study #8 of 320   Meta Analysis
3/31 Late treatment study
Chen et al., medRxiv doi:10.1101/2020.03.22.20040758 (Preprint)
Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial
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62 patients. RCT showing significantly faster recovery with HCQ. 13% progressed to severe cases in the control group, versus 0% for the treatment group. Significant improvement seen in pneumonia on chest CT for 61% of treated patients and 16% of control patients.

Chen et al., 3/31/2020, Randomized Controlled Trial, China, Asia, preprint, 9 authors.
risk of no improvement in pneumonia at day 6, 57.0% lower, RR 0.43, p = 0.04, treatment 6 of 31 (19.4%), control 14 of 31 (45.2%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 320 studies   Meta Analysis
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