Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial

3/31 Late treatment study

Chen et al., medRxiv doi:10.1101/2020.03.22.20040758 (Preprint)
Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial

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62 patients. RCT showing significantly faster recovery with HCQ. 13% progressed to severe cases in the control group, versus 0% for the treatment group. Significant improvement seen in pneumonia on chest CT for 61% of treated patients and 16% of control patients.

Chen et al., 3/31/2020, Randomized Controlled Trial, China, Asia, preprint, 9 authors.

risk of no improvement in pneumonia at day 6, 57.0% lower, RR 0.43, p = 0.04, treatment 6 of 31 (19.4%), control 14 of 31 (45.2%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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