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0 0.5 1 1.5 2+ Mortality 70% Improvement Relative Risk Mortality (b) 67% early Mortality (c) 77% Mortality (d) 84% Mortality (e) -29% c19hcq.com Corradini et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Corradini, 1,713 patient HCQ late treatment study: 70% lower mortality [p<0.0001] https://c19p.org/corradini
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Clinical factors associated with death in 3044 COVID-19 patients managed in internal medicine wards in Italy: results from the SIMI-COVID-19 study of the Italian Society of Internal Medicine (SIMI)
Corradini et al., Internal and Emergency Medicine, doi:10.1007/s11739-021-02742-8
24 Apr 2021    Source   PDF   Share   Tweet
Retrospective 3,044 hospitalized COVID-19 patients in Italy, showing HCQ significantly associated with survival in light, mild, and moderate cases in multivariable analysis, but not in severe cases.
risk of death, 70.2% lower, OR 0.30, p < 0.001, treatment 1,439, control 274, adjusted per study, Table S6, all patients, multivariable, RR approximated with OR.
risk of death, 67.4% lower, OR 0.33, p = 0.01, treatment 641, control 102, adjusted per study, Table S6, light condition patients, multivariable, RR approximated with OR, early treatment result.
risk of death, 76.8% lower, OR 0.23, p < 0.001, treatment 546, control 71, adjusted per study, Table S6, mild condition patients, multivariable, RR approximated with OR.
risk of death, 84.2% lower, OR 0.16, p < 0.001, treatment 184, control 64, adjusted per study, Table S6, moderate condition patients, multivariable, RR approximated with OR.
risk of death, 29.0% higher, OR 1.29, p = 0.73, treatment 68, control 37, adjusted per study, Table S6, severe condition patients, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Corradini et al., 4/24/2021, retrospective, Italy, Europe, peer-reviewed, 60 authors, dosage not specified.
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Late treatment
is less effective
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