Impact of medical care including anti-infective agents use on the prognosis of COVID-19 hospitalized patients over time
et al., Int. J. Antimicrobial Agents, 2020,
Retrospective of 132 hospitalized patients. HCQ+AZ(52)/AZ(28) significantly reduced death/ICU, HR=0.45, p=0.04. Adjusted for Charlson Comorbidity Index (including age), obesity, O2, lymphocyte count, and treatments. Mean delay from admission to treatment 0.7 days.
risk of intubation/hospitalization, 55.0% lower, HR 0.45, p = 0.04, treatment 12 of 80 (15.0%), control 13 of 40 (32.5%), NNT 5.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Davido et al., 8/2/2020, retrospective, France, Europe, peer-reviewed, 14 authors.