Del Amo: Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo controlled randomized trial in healthcare workers

Del Amo, 454 patient HCQ prophylaxis RCT: 27% fewer cases [p=0.31] https://c19p.org/delamo

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Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo controlled randomized trial in healthcare workers

Del Amo, J., medRxiv, doi:10.1101/2022.03.02.22271710 (Preprint), EPICOS, NCT04334928 (history)

4 Mar 2022 Source PDF Share Tweet

PrEP RCT with 231 HCQ, 220 TDF/FTC+HCQ, 233 TDF/FTC, and 223 placebo healthcare workers in Spain, Bolivia, and Venezuela, showing lower risk of symptomatic COVID-19 in all treatment arms, without statistical significance. Only 907 of the planned 4,000 participants were recruited. EudraCT number 2020-001385-11.

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risk of symptomatic case, 51.0% lower, RR 0.49, p = 0.79, treatment 3 of 231 (1.3%), control 5 of 223 (2.2%), NNT 106, HCQ, Kaplan–Meier.

risk of symptomatic case, 61.0% lower, RR 0.39, p = 0.72, treatment 3 of 220 (1.4%), control 5 of 223 (2.2%), TDF+HCQ, Kaplan–Meier.

risk of case, 27.0% lower, RR 0.73, p = 0.31, treatment 21 of 231 (9.1%), control 23 of 223 (10.3%), HCQ, Kaplan–Meier.

risk of case, 49.0% lower, RR 0.51, p = 0.09, treatment 13 of 220 (5.9%), control 23 of 223 (10.3%), NNT 23, TDF+HCQ, Kaplan–Meier.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Del Amo et al., 4 Mar 2022, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, preprint, 1 author, study period April 2020 - May 2021, dosage 200mg daily, trial NCT04334928 (history) (EPICOS).

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