Antiandrogens
Aspirin
Bromhexine
Budesonide
Cannabidiol
Casirivimab/i..
Colchicine
Conv. Plasma
Curcumin
Diet
Ensovibep
Exercise
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Melatonin
Metformin
Molnupiravir
Nigella Sativa
Nitazoxanide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Proxalutamide
Quercetin
Remdesivir
Sleep
Sotrovimab
Vitamin A
Vitamin C
Vitamin D
Zinc

Other
Feedback Home
Home   COVID-19 treatment studies for Hydroxychloroquine  COVID-19 treatment studies for HCQ  C19 studies: HCQ  HCQ   Select treatmentSelect treatmentTreatmentsTreatments
Antiandrogens (meta) Lactoferrin (meta)
Aspirin (meta) Melatonin (meta)
Bamlaniv../e.. (meta) Metformin (meta)
Bebtelovimab (meta) Molnupiravir (meta)
Bromhexine (meta) N-acetylcys.. (meta)
Budesonide (meta) Nigella Sativa (meta)
Cannabidiol (meta) Nitazoxanide (meta)
Casirivimab/i.. (meta) Paxlovid (meta)
Colchicine (meta) Peg.. Lambda (meta)
Conv. Plasma (meta) Povidone-Iod.. (meta)
Curcumin (meta) Probiotics (meta)
Diet (meta) Proxalutamide (meta)
Ensitrelvir (meta) Quercetin (meta)
Ensovibep (meta) Remdesivir (meta)
Exercise (meta) Sleep (meta)
Famotidine (meta) Sotrovimab (meta)
Favipiravir (meta) Tixagev../c.. (meta)
Fluvoxamine (meta) Vitamin A (meta)
Hydroxychlor.. (meta) Vitamin C (meta)
Iota-carragee.. (meta) Vitamin D (meta)
Ivermectin (meta) Zinc (meta)

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Symptomatic case 51% Improvement Relative Risk Symptomatic case (b) 61% Case 27% Case (b) 49% c19hcq.com Del Amo et al. NCT04334928 HCQ RCT PrEP Favors HCQ Favors control
Del Amo, 454 patient HCQ prophylaxis RCT: 27% fewer cases [p=0.31] https://c19p.org/delamo
copied to clipboard
Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo controlled randomized trial in healthcare workers
Del Amo, J., medRxiv, doi:10.1101/2022.03.02.22271710 (Preprint)
4 Mar 2022    Source   PDF   Share   Tweet
PrEP RCT with 231 HCQ, 220 TDF/FTC+HCQ, 233 TDF/FTC, and 223 placebo healthcare workers in Spain, Bolivia, and Venezuela, showing lower risk of symptomatic COVID-19 in all treatment arms, without statistical significance. Only 907 of the planned 4,000 participants were recruited. EPICOS. NCT04334928. EudraCT number 2020-001385-11.
risk of symptomatic case, 51.0% lower, RR 0.49, p = 0.79, treatment 3 of 231 (1.3%), control 5 of 223 (2.2%), NNT 106, HCQ, Kaplan–Meier.
risk of symptomatic case, 61.0% lower, RR 0.39, p = 0.72, treatment 3 of 220 (1.4%), control 5 of 223 (2.2%), TDF+HCQ, Kaplan–Meier.
risk of case, 27.0% lower, RR 0.73, p = 0.31, treatment 21 of 231 (9.1%), control 23 of 223 (10.3%), HCQ, Kaplan–Meier.
risk of case, 49.0% lower, RR 0.51, p = 0.09, treatment 13 of 220 (5.9%), control 23 of 223 (10.3%), NNT 23, TDF+HCQ, Kaplan–Meier.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Del Amo et al., 3/4/2022, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, multiple regions, preprint, 1 author, study period April 2020 - May 2021, dosage 200mg daily, trial NCT04334928.
All Studies   Meta Analysis
This PaperHCQAll
Please send us corrections, updates, or comments. Vaccines and treatments are both valuable and complementary. All practical, effective, and safe means should be used. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases mortality, morbidity, collateral damage, and the risk of endemic status. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit