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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -105% Improvement Relative Risk c19hcq.com/deluna.html Favors HCQ Favors control
14 December 2020 - Late treatment study
Clinical and Demographic Characteristics of COVID-19 Patients Admitted in a Tertiary Care Hospital in the Dominican Republic
De Luna et al., medRxiv, doi:10.1101/2020.12.11.20247437 (Preprint)
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Retrospective 150 patients in the Dominican Republic, 132 treated with HCQ, showing higher mortality with treatment in unadjusted results. Confounding by indication is likely.
risk of death, 104.5% higher, RR 2.05, p = 0.69, treatment 15 of 132 (11.4%), control 1 of 18 (5.6%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details, substantial unadjusted confounding by indication likely.
De Luna et al., 12/14/2020, retrospective, Dominican Republic, Caribbean, preprint, 10 authors.
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