Retrospective 150 patients in the Dominican Republic, 132 treated with HCQ, showing higher mortality with treatment in unadjusted results. Confounding by indication is likely.
De Luna et al., 12/14/2020, retrospective, Dominican Republic, Caribbean, preprint, 10 authors.
risk of death, 104.5% higher, RR 2.05, p = 0.69, treatment 15 of 132 (11.4%), control 1 of 18 (5.6%).
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details, substantial unadjusted confounding by indication likely.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.