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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 35% Improvement Relative Risk Mortality (b) 36% c19hcq.com/derosa.html Favors HCQ Favors control
1 May 2021 - Late treatment study
Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry
De Rosa et al., J. Clin. Med., doi:10.3390/jcm10091951 (Peer Reviewed)
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Retrospective 1,538 hospitalized patients in Italy, showing only HCQ associated with reduced mortality. Authors analyze mortality amongst those that were alive at day 7 to avoid survival time bias due to drug recording requiring a minimum of 5 days treatment.
risk of death, 35.0% lower, RR 0.65, p = 0.02, treatment 118 of 731 (16.1%), control 80 of 280 (28.6%), NNT 8.0, adjusted per study, odds ratio converted to relative risk, multivariate logistic regression, patients alive at day 7.
risk of death, 36.0% lower, RR 0.64, p < 0.001, treatment 207 of 1,019 (20.3%), control 215 of 519 (41.4%), NNT 4.7, adjusted per study, odds ratio converted to relative risk, multivariate logistic regression, all patients.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
De Rosa et al., 5/1/2021, retrospective, Italy, Europe, peer-reviewed, 20 authors.
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