Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry

5/1 Late treatment study

De Rosa et al., J. Clin. Med., doi:10.3390/jcm10091951 (Peer Reviewed)
Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry

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Retrospective 1,538 hospitalized patients in Italy, showing only HCQ associated with reduced mortality. Authors analyze mortality amongst those that were alive at day 7 to avoid survival time bias due to drug recording requiring a minimum of 5 days treatment.

De Rosa et al., 5/1/2021, retrospective, Italy, Europe, peer-reviewed, 20 authors.

risk of death, 35.0% lower, RR 0.65, p = 0.003, treatment 118 of 731 (16.1%), control 80 of 280 (28.6%), adjusted per study, odds ratio converted to relative risk, multivariate logistic regression, patients alive at day 7.

risk of death, 36.0% lower, RR 0.64, treatment 207 of 1019 (20.3%), control 215 of 519 (41.4%), adjusted per study, odds ratio converted to relative risk, multivariate logistic regression, all patients.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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