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HCQ study #312 of 355   Meta Analysis
5/1 Late treatment study
De Rosa et al., J. Clin. Med., doi:10.3390/jcm10091951 (Peer Reviewed)
Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry
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Retrospective 1,538 hospitalized patients in Italy, showing only HCQ associated with reduced mortality. Authors analyze mortality amongst those that were alive at day 7 to avoid survival time bias due to drug recording requiring a minimum of 5 days treatment.
De Rosa et al., 5/1/2021, retrospective, Italy, Europe, peer-reviewed, 20 authors.
risk of death, 35.0% lower, RR 0.65, p = 0.003, treatment 118 of 731 (16.1%), control 80 of 280 (28.6%), adjusted per study, odds ratio converted to relative risk, multivariate logistic regression, patients alive at day 7.
risk of death, 36.0% lower, RR 0.64, treatment 207 of 1019 (20.3%), control 215 of 519 (41.4%), adjusted per study, odds ratio converted to relative risk, multivariate logistic regression, all patients.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 355 studies   Meta Analysis
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