Retrospective 199 sarcoidosis patients showing non-statistically significant HCQ RR 0.83, p
Desbois et al., 7/20/2020, retrospective, France, Europe, preprint, mean age 58.8, 13 authors.
risk of COVID-19 case, 16.9% lower, RR 0.83, p = 1.00, treatment 3 of 27 (11.1%), control 23 of 172 (13.4%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.