Prevalence and clinical features of COVID-19 in a large cohort of 199 patients with sarcoidosis

7/20 Pre-Exposure Prophylaxis study (treated before exposed to the virus)

Desbois et al., Research Square, doi:10.21203/rs.3.rs-41653/v1 (Preprint)
Prevalence and clinical features of COVID-19 in a large cohort of 199 patients with sarcoidosis

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Retrospective 199 sarcoidosis patients showing non-statistically significant HCQ RR 0.83, p=1.0.

Desbois et al., 7/20/2020, retrospective, France, Europe, preprint, mean age 58.8, 13 authors.

risk of COVID-19 case, 16.9% lower, RR 0.83, p = 1.00, treatment 3 of 27 (11.1%), control 23 of 172 (13.4%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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