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HCQ study #121 of 257
8/25 Late treatment study
Di Castelnuovo et al., European J. Internal Medicine, doi:10.1016/j.ejim.2020.08.019 (Peer Reviewed)
Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study
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Retrospective 3,451 hospitalized patients, 30% reduction in mortality with HCQ after propensity adjustment, HR 0.70 [0.59 - 0.84].

Di Castelnuovo et al., 8/25/2020, retrospective, Italy, Europe, peer-reviewed, 110 authors.
risk of death, 30.0% lower, RR 0.70, p < 0.001, treatment 386 of 2634 (14.7%), control 90 of 817 (11.0%), adjusted per study.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Details of all 257 studies    Meta analysis
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