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0 0.5 1 1.5 2+ Mortality 40% Improvement Relative Risk c19hcq.com Di Castelnuovo et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Di Castelnuovo, 4,270 patient HCQ late treatment study: 40% lower mortality [p<0.0001] https://c19p.org/dicastelnuovo2
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Disentangling the Association of Hydroxychloroquine Treatment with Mortality in Covid-19 Hospitalized Patients through Hierarchical Clustering
Di Castelnuovo et al., Journal of Healthcare Engineering, doi:10.1155/2021/5556207 (preprint 1/29/2021)
29 Jan 2021    Source   PDF   Share   Tweet
Retrospective 4,396 hospitalized patients in Italy showing significantly lower mortality with HCQ treatment, and identifying greater efficacy for a subgroup of patients in clustering analysis.
risk of death, 40.0% lower, RR 0.60, p < 0.001, treatment 3,270, control 1,000, odds ratio converted to relative risk, multivariate Cox proportional hazards model 4, control prevalence approximated with overall prevalence.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Di Castelnuovo et al., 1/29/2021, retrospective, Italy, Europe, peer-reviewed, 112 authors.
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Late treatment
is less effective
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