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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Death at day 29 6% Improvement Relative Risk c19hcq.com/discovery.html Favors HCQ Favors control
6 October 2020 - Late treatment study
An open-label randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19
Ader et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2021.05.020 (Peer Reviewed)
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Early terminated very late stage (95% on oxygen at baseline) DISCOVERY trial. 4% more patients were on ventilation at baseline in the HCQ group.
risk of death at day 29, 6.4% lower, RR 0.94, p = 1.00, treatment 11 of 145 (7.6%), control 12 of 148 (8.1%), NNT 192.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
This study is excluded in the after exclusion results of meta analysis: very late stage, >50% on oxygen/ventilation at baseline.
Ader et al., 10/6/2020, Randomized Controlled Trial, multiple countries, multiple regions, peer-reviewed, baseline oxygen requirements 95.4%, 58 authors.
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