Antiviral drugs in hospitalized patients with COVID-19

10/6 Late treatment study

Ader et al., medRxiv, doi:10.1101/2021.01.08.20248149 (news 10/6) (Preprint)
Antiviral drugs in hospitalized patients with COVID-19 - the DisCoVeRy trial

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Early terminated very late stage (95% on oxygen at baseline) DISCOVERY trial. 4% more patients were on ventilation at baseline in the HCQ group.

Ader et al., 10/6/2020, Randomized Controlled Trial, multiple countries, multiple regions, preprint, baseline oxygen requirements 95.4%, 52 authors.

risk of death at day 29, 6.4% lower, RR 0.94, p = 1.00, treatment 11 of 145 (7.6%), control 12 of 148 (8.1%).

This study is excluded in meta analysis: very late stage, >50% on oxygen/ventilation at baseline.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 344 studies Meta Analysis

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