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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 37% Improvement Relative Risk Mortality (b) 24% c19hcq.com/frontera.html Favors HCQ Favors control
26 October 2020 - Late treatment study
Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study
Frontera et al., Research Square, doi:10.21203/rs.3.rs-94509/v1 (Preprint)
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Retrospective 3,473 hospitalized patients showing lower mortality with HCQ+zinc.
risk of death, 37.0% lower, RR 0.63, p = 0.01, treatment 121 of 1,006 (12.0%), control 424 of 2,467 (17.2%), NNT 19, adjusted per study, PSM.
risk of death, 24.0% lower, RR 0.76, p = 0.02, treatment 121 of 1,006 (12.0%), control 424 of 2,467 (17.2%), NNT 19, adjusted per study, regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Frontera et al., 10/26/2020, retrospective, propensity score matching, USA, North America, preprint, median age 64.0, 14 authors, this trial uses multiple treatments in the treatment arm (combined with zinc) - results of individual treatments may vary.
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