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HCQ study #167 of 260
10/26 Late treatment study
Frontera et al., Research Square, doi:10.21203/ (Preprint)
Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study
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Retrospective 3,473 hospitalized patients showing lower mortality with HCQ+zinc.

Frontera et al., 10/26/2020, retrospective, USA, North America, preprint, median age 64.0, 14 authors.
risk of death, 37.0% lower, RR 0.63, p = 0.01, treatment 121 of 1006 (12.0%), control 424 of 2467 (17.2%), adjusted per study, PSM.
risk of death, 24.0% lower, RR 0.76, p = 0.02, treatment 121 of 1006 (12.0%), control 424 of 2467 (17.2%), adjusted per study, regression.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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