1 October 2021 - Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Effect of common maintenance drugs on the risk and severity of COVID-19 in elderly patients
et al., medRxiv, doi:10.1101/2021.09.28.21264186 (Preprint)
Retrospective database analysis of 374,229 patients in the USA, showing no significant difference with HCQ use, however authors do not adjust for the very different baseline risk for systemic autoimmune disease patients. Other research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall, Ferri et al. show OR 4.42, p<0.001 [1].Authors compare with patients that never used HCQ and with patients that previously used HCQ. The comparison with patients previously using HCQ is more relevant because the matching of patients with systemic autoimmune disease is likely to be better.
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risk of death, 15.0% lower, RR 0.85, p = 0.10, vs. past use (better match for systemic autoimmune diseases).
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risk of hospitalization, 5.0% lower, RR 0.95, p = 0.41, vs. past use (better match for systemic autoimmune diseases).
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risk of case, 10.0% lower, RR 0.90, p = 0.004, vs. past use (better match for systemic autoimmune diseases).
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risk of death, 6.0% higher, RR 1.06, p = 0.39, vs. never used.
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risk of hospitalization, 4.0% higher, RR 1.04, p = 0.32, vs. never used.
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risk of case, 5.0% lower, RR 0.95, p = 0.06, vs. never used.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. |
This study is excluded in the after exclusion results of meta
analysis:
not fully adjusting for the different baseline risk of systemic autoimmune patients.
Fung et al., 10/1/2021, retrospective, population-based cohort, USA, North America, preprint, 6 authors.
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