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Remdesivir study #13 of 32   All Outcomes
11/20 Late treatment study
Garibaldi et al., medRxiv, doi:10.1101/2020.11.19.20234153 (Preprint)
Effectiveness of remdesivir with and without dexamethasone in hospitalized patients with COVID-19
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Retrospective 303 remdesivir patients and 303 matched controls showing significantly faster clinical improvement, and lower (but not statistically significant) mortality.
Garibaldi et al., 11/20/2020, retrospective, USA, North America, preprint, 10 authors.
risk of death, 20.0% lower, RR 0.80, p = 0.44, treatment 23 of 303 (7.6%), control 45 of 303 (14.9%), adjusted per study.
risk of no improvement at day 28, 35.0% lower, RR 0.65, p < 0.001, treatment 52 of 303 (17.2%), control 80 of 303 (26.4%), adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 32 studies   All Outcomes
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