Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

5/8 Ex Vivo

Grassin-Delyle et al., Clinical Infectious Diseases, doi:10.1093/cid/ciaa546 (Peer Reviewed) (Ex Vivo)
Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

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On human lung parenchymal explants, CQ concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). In addition to antiviral activity, CQ may also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.

Grassin-Delyle et al., 5/8/2020, peer-reviewed, 8 authors.

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