Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants
et al., Clinical Infectious Diseases, doi:10.1093/cid/ciaa546 (Ex Vivo)
On human lung parenchymal explants, CQ concentration clinically achievable in the lung (100µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). In addition to antiviral activity, CQ may also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.
Grassin-Delyle et al., 5/8/2020, peer-reviewed, 8 authors.
Ex Vivo studies are an important part of preclinical research, however results may be very different in vivo.
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