Retrospective 600 hospitalized patients in Italy, showing lower mortality with HCQ treatment, without reaching statistical significance (p
risk of death, 28.0% lower, RR 0.72, p = 0.10, treatment 474, control 126, multivariable Cox proportional hazards.
Guglielmetti et al., 10/25/2021, retrospective, Italy, Europe, peer-reviewed, 19 authors.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.