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HCQ study #361   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 28% Imp. Relative Risk, 95% CI Guglielmetti: Treatment for COVID-19—a cohort study from Northern Italy c19hcq.com/guglielmetti2.html Favors HCQ Favors control
10/25 Late treatment study
Guglielmetti et al., Scientific Reports, doi:10.1038/s41598-021-00243-4 (Peer Reviewed)
Treatment for COVID-19—a cohort study from Northern Italy
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Retrospective 600 hospitalized patients in Italy, showing lower mortality with HCQ treatment, without reaching statistical significance (p = 0.1).
risk of death, 28.0% lower, RR 0.72, p = 0.10, treatment 474, control 126, multivariable Cox proportional hazards.
Guglielmetti et al., 10/25/2021, retrospective, Italy, Europe, peer-reviewed, 19 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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