et al., JAMA Intern. Med., doi:10.1001/jamainternmed.2020.3596 (Peer Reviewed)
Analysis of 2215 intensive care unit patients showing no significant differences with this very late stage use of HCQ. HCQ+AZ mortality relative risk RR 0.96, p
=0.53, HCQ and HCQ+AZ combined RR 1.06, p
Gupta et al., 7/15/2020, retrospective, USA, North America, peer-reviewed, baseline oxygen requirements 87.1%, 34 authors.
risk of death, 6.0% higher, RR 1.06, p = 0.41, treatment 631 of 1761 (35.8%), control 153 of 454 (33.7%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.