Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US

7/15 Late treatment study

Gupta et al., JAMA Intern. Med., doi:10.1001/jamainternmed.2020.3596 (Peer Reviewed)
Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US

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Analysis of 2215 intensive care unit patients showing no significant differences with this very late stage use of HCQ. HCQ+AZ mortality relative risk RR 0.96, p=0.53, HCQ and HCQ+AZ combined RR 1.06, p=0.409.

Gupta et al., 7/15/2020, retrospective, USA, North America, peer-reviewed, baseline oxygen requirements 87.1%, 34 authors.

risk of death, 6.0% higher, RR 1.06, p = 0.41, treatment 631 of 1761 (35.8%), control 153 of 454 (33.7%).

This study is excluded in meta analysis: very late stage, >50% on oxygen/ventilation at baseline.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 344 studies Meta Analysis

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